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Revision as of 22:07, 2 August 2025


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Figure 6. Glycogen metabolism underlies reminiscence consolidation. Glycogen, positioned in astrocytes in the hippocampus, is metabolized to lactate, which is transported to the pre and postsynaptic terminals, the place it fulfils separate roles, being transformed to glutamate in the presynaptic terminal, and aiding consolidation in the postsynaptic terminal. Recently it has been proven that neuronal exercise regulates many astrocytic genes, particularly up-regulation of genes associated with glycolysis and lactate, however not oxidative metabolism. The dogmatic view of cellular expression of glycogen in the mind is that it's solely loctated in astrocytes in adults, and is barely expressed in neurones during growth (Bloom and Fawcett, 1968; Magistretti et al., 1993a) or on account of pathology (Vilchez et al., 2007). However with age neurons present an increased capability to metabolize glycogen and perform glycolysis, thereby demonstrating a shift from dependence to independence on astrocytic lactate (Drulis-Fajdasz et al., 2018). The reasons for this are unknown but might nicely have significance to an aging inhabitants.